Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

An initial step in amyloid-β (Aβ) production includes amyloid precursor protein (APP) cleavage via β-Site amyloid precursor protein cleaving enzyme 1 (BACE1). Increased levels of brain Aβ have been implicated in the pathogenesis of Alzheimer’s disease (AD). Thus, β-secretase represents a primary tar...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Liang, Huiyu, Shi, Yusheng, Kou, Zhewen, Peng, Yonghua, Chen, Wenjun, Li, Xiaowen, Li, Shuji, Wang, Ying, Wang, Fang, Zhang, Xingmei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608735/
https://ncbi.nlm.nih.gov/pubmed/26473367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140733
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