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Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model
An initial step in amyloid-β (Aβ) production includes amyloid precursor protein (APP) cleavage via β-Site amyloid precursor protein cleaving enzyme 1 (BACE1). Increased levels of brain Aβ have been implicated in the pathogenesis of Alzheimer’s disease (AD). Thus, β-secretase represents a primary tar...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4608735/ https://ncbi.nlm.nih.gov/pubmed/26473367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140733 |
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