Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats

The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity. Inflammasomes recognize microbial and host-d...

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Udgivet i:PLoS One
Main Authors: Zhao, Jing, Mou, Yongshan, Bernstock, Joshua D., Klimanis, Dace, Wang, Sixian, Spatz, Maria, Maric, Dragan, Johnson, Kory, Klinman, Dennis M., Li, Xiaohong, Li, Xinhui, Hallenbeck, John M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608557/
https://ncbi.nlm.nih.gov/pubmed/26473731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140772
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