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Metabolically Programmed Iron Chelators
Extensive structure activity relationship (SAR) studies focused on the desferrithiocin [DFT, (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid] pharmacophore have led to three different DFT analogues being evaluated clinically for the treatment of iron overload diseases, e...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4608554/ https://ncbi.nlm.nih.gov/pubmed/26231739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.059 |
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