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The Design, Synthesis, and Evaluation of Organ-Specific Iron Chelators

A series of iron chelators, three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid (DADFT) and three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid (DADMDFT) analogues are synthesized and assessed for their lipophilicity (log P(app)), iron-clearing efficiency (IC...

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Bibliographic Details
Main Authors: Bergeron, Raymond J., Wiegand, Jan, McManis, James S., Bharti, Neelam
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516204/
https://ncbi.nlm.nih.gov/pubmed/17125256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0608816
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