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Desferrithiocin Analogue Iron Chelators: Iron Clearing Efficiency, Tissue Distribution, and Renal Toxicity

The current solution to iron-mediated damage in transfusional iron overload disorders is decorporation of excess unmanaged metal, chelation therapy. The clinical development of the tridentate chelator deferitrin (1, Table 1) was halted due to nephrotoxicity. It was then shown by replacing the 4′-(HO...

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Библиографические подробности
Главные авторы: Bergeron, Raymond J., Wiegand, Jan, Bharti, Neelam, McManis, James S., Singh, Shailendra
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329216/
https://ncbi.nlm.nih.gov/pubmed/21103911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-010-9389-y
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