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Desferrithiocin Analogue Iron Chelators: Iron Clearing Efficiency, Tissue Distribution, and Renal Toxicity

The current solution to iron-mediated damage in transfusional iron overload disorders is decorporation of excess unmanaged metal, chelation therapy. The clinical development of the tridentate chelator deferitrin (1, Table 1) was halted due to nephrotoxicity. It was then shown by replacing the 4′-(HO...

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Bibliographic Details
Main Authors: Bergeron, Raymond J., Wiegand, Jan, Bharti, Neelam, McManis, James S., Singh, Shailendra
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329216/
https://ncbi.nlm.nih.gov/pubmed/21103911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-010-9389-y
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