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Desferrithiocin Analogue Iron Chelators: Iron Clearing Efficiency, Tissue Distribution, and Renal Toxicity

The current solution to iron-mediated damage in transfusional iron overload disorders is decorporation of excess unmanaged metal, chelation therapy. The clinical development of the tridentate chelator deferitrin (1, Table 1) was halted due to nephrotoxicity. It was then shown by replacing the 4′-(HO...

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Autors principals: Bergeron, Raymond J., Wiegand, Jan, Bharti, Neelam, McManis, James S., Singh, Shailendra
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329216/
https://ncbi.nlm.nih.gov/pubmed/21103911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-010-9389-y
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