Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that incorporate a 7-indolizinylamino or 2-naphthylamino substituent on a pyrimidine or 1,3,5-triazine core. The most potent compounds show below 10 nanomolar activity towards wild-type HIV-1 and variants bearing Tyr181Cy...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Lee, Won-Gil, Frey, Kathleen M., Gallardo-Macias, Ricardo, Spasov, Krasimir A., Chan, Albert H., Anderson, Karen S., Jorgensen, William L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607639/
https://ncbi.nlm.nih.gov/pubmed/26166629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.074
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