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Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock

Nuclear factor-kappa B (NF-κB) activation is widely implicated in multiple organ failure (MOF); however, a direct inhibitor of IκB kinase (IKK), which plays a pivotal role in the activation of NF-κB, has not been investigated in shock. Thus, the aim of the present work was to investigate the effects...

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Publicat a:Mol Med
Autors principals: Sordi, Regina, Chiazza, Fausto, Johnson, Florence L, Patel, Nimesh S A, Brohi, Karim, Collino, Massimo, Thiemermann, Christoph
Format: Artigo
Idioma:Inglês
Publicat: ScholarOne 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607620/
https://ncbi.nlm.nih.gov/pubmed/26101953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00049
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