‘Preconditioning’ with Low Dose Lipopolysaccharide Aggravates the Organ Injury / Dysfunction Caused by Hemorrhagic Shock in Rats

METHODS: Male rats were ‘pretreated’ with phosphate-buffered saline (PBS; i.p.) or LPS (1 mg/kg; i.p.) 24 h prior to HS. Mean arterial pressure (MAP) was maintained at 30 ± 2 mmHg for 90 min or until 25% of the shed blood had to be re-injected to sustain MAP. This was followed by resuscitation with...

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Foilsithe in:PLoS One
Main Authors: Sordi, Regina, Chiazza, Fausto, Patel, Nimesh S. A., Doyle, Rachel A., Collino, Massimo, Thiemermann, Christoph
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382161/
https://ncbi.nlm.nih.gov/pubmed/25830444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122096
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