Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Singh, Bhupendra, Owens, Kjerstin M., Bajpai, Prachi, Desouki, Mohamed Mokhtar, Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Singh, Keshav K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://ncbi.nlm.nih.gov/pubmed/26468652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139846
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