Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Singh, Bhupendra, Owens, Kjerstin M., Bajpai, Prachi, Desouki, Mohamed Mokhtar, Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Singh, Keshav K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://ncbi.nlm.nih.gov/pubmed/26468652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139846
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