Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Singh, Bhupendra, Owens, Kjerstin M., Bajpai, Prachi, Desouki, Mohamed Mokhtar, Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Singh, Keshav K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://ncbi.nlm.nih.gov/pubmed/26468652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139846
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