Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Singh, Bhupendra, Owens, Kjerstin M., Bajpai, Prachi, Desouki, Mohamed Mokhtar, Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Singh, Keshav K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://ncbi.nlm.nih.gov/pubmed/26468652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139846
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