Aurora A inhibitor (MLN8237) plus Vincristine plus Rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma

PURPOSE: Aurora A and B are oncogenic serine/threonine kinases that regulate mitosis. Over-expression of Auroras promotes resistance to microtubule targeted agents. We investigated mechanistic synergy by inhibiting the mitotic spindle apparatus in the presence of MLN8237 [M], an Aurora A inhibitor w...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Mahadevan, Daruka, Stejskal, Amy, Cooke, Laurence S., Manziello, Ann, Morales, Carla, Persky, Daniel O., Fisher, Richard I., Miller, Thomas P., Qi, Wenqing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607283/
https://ncbi.nlm.nih.gov/pubmed/22374334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2413
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