Alisertib Added to Rituximab and Vincristine Is Synthetic Lethal and Potentially Curative in Mice with Aggressive DLBCL Co-Overexpressing MYC and BCL2

Pearson correlation coefficient for expression analysis of the Lymphoma/Leukemia Molecular Profiling Project (LLMPP) demonstrated Aurora A and B are highly correlated with MYC in DLBCL and mantle cell lymphoma (MCL), while both Auroras correlate with BCL2 only in DLBCL. Auroras are up-regulated by M...

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Detalhes bibliográficos
Main Authors: Mahadevan, Daruka, Morales, Carla, Cooke, Laurence S., Manziello, Ann, Mount, David W., Persky, Daniel O., Fisher, Richard I., Miller, Thomas P., Qi, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043492/
https://ncbi.nlm.nih.gov/pubmed/24893165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095184
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