Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase

OBJECTIVE: To find out whether dexamethasone induces an uncoupling of the endothelial nitric oxide synthase (eNOS). METHODS & RESULTS: A major cause of eNOS uncoupling is a deficiency of its cofactor tetrahydrobiopterin (BH(4)). Treatment of human EA.hy 926 endothelial cells with dexamethasone d...

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Udgivet i:J Geriatr Cardiol
Main Authors: Tobias, Silke, Habermeier, Alice, Siuda, Daniel, Reifenberg, Gisela, Xia, Ning, Closs, Ellen I, Förstermann, Ulrich, Li, Huige
Format: Artigo
Sprog:Inglês
Udgivet: Science Press 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605949/
https://ncbi.nlm.nih.gov/pubmed/26512245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.11909/j.issn.1671-5411.2015.05.013
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