Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become “uncoupled,” producing reactive oxygen species (ROSs) rather than NO. In aortas of mice with deoxycorticosterone acetate–salt (DOCA-salt) hypertension, ROS production from NO synthase is markedly...

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Détails bibliographiques
Auteurs principaux: Landmesser, Ulf, Dikalov, Sergey, Price, S. Russ, McCann, Louise, Fukai, Tohru, Holland, Steven M., Mitch, William E., Harrison, David G.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC152929/
https://ncbi.nlm.nih.gov/pubmed/12697739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200314172
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