Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow

OBJECTIVE: Tetrahydrobiopterin (BH(4)) is a critical cofactor for Nitric Oxide (NO) synthesis by NO synthase (NOS). Recently, we demonstrated that disturbed flow produced by partial carotid ligation decreases BH(4) levels in vivo. We therefore aimed to determine whether atherosclerosis induced by di...

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Hlavní autoři: Li, Li, Chen, Wei, Rezvan, Amir, Jo, Hanjoong, Harrison, David G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117114/
https://ncbi.nlm.nih.gov/pubmed/21512164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.226456
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