A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks. Work with budding yeast showed that the ‘alternative clamp loader’ known as Ctf18-R...

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Publicat a:Nucleic Acids Res
Autors principals: García-Rodríguez, Luis J., De Piccoli, Giacomo, Marchesi, Vanessa, Jones, Richard C., Edmondson, Ricky D., Labib, Karim
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605302/
https://ncbi.nlm.nih.gov/pubmed/26250113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv799
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