Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication

The eukaryotic replisome must faithfully replicate DNA and cope with replication fork blocks and stalling, while simultaneously promoting sister chromatid cohesion. Ctf18-RFC is an alternative PCNA loader that links all these processes together by an unknown mechanism. Here, we use integrative struc...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Stokes, Katy, Winczura, Alicja, Song, Boyuan, De Piccoli, Giacomo, Grabarczyk, Daniel B
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641331/
https://ncbi.nlm.nih.gov/pubmed/32585006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa541
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