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A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1
Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks. Work with budding yeast showed that the ‘alternative clamp loader’ known as Ctf18-R...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605302/ https://ncbi.nlm.nih.gov/pubmed/26250113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv799 |
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