Validation of the In Vivo Assessment of Pyruvate Dehydrogenase Activity Using Hyperpolarized (13)C-Magnetic Resonance Spectroscopy

AIM: Many diseases of the heart are characterised by changes in substrate utilisation, which is in part regulated by the activity of the enzyme pyruvate dehydrogenase (PDH). Consequently, there is much interest in the in vivo evaluation of PDH activity in a range of physiological and pathological st...

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Udgivet i:NMR Biomed
Main Authors: Atherton, Helen J., Schroeder, Marie A., Dodd, Michael S., Heather, Lisa C., Carter, Emma E., Cochlin, Lowri E., Nagel, Simon, Sibson, Nicola R., Radda, George K., Clarke, Kieran, Tyler, Damian J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604661/
https://ncbi.nlm.nih.gov/pubmed/20799252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.1573
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