Lack of Mutational Hot Spots during Decitabine-Mediated HIV-1 Mutagenesis

Decitabine has previously been shown to induce lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1). However, the factors that determine the susceptibilities of individual sequence positions in HIV-1 to decitabine have not yet been defined. To investigate this, we performed Illumina hig...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Rawson, Jonathan M. O., Landman, Sean R., Reilly, Cavan S., Bonnac, Laurent, Patterson, Steven E., Mansky, Louis M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604356/
https://ncbi.nlm.nih.gov/pubmed/26282416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01644-15
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