Population Pharmacokinetics of Piperacillin in the Early Phase of Septic Shock: Does Standard Dosing Result in Therapeutic Plasma Concentrations?

Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the pharmacokinetic (PK) variability seen in this patient population. Piperacillin-tazobactam is often used for empirical treatment, and initial appropriate dosing is crucial for reducing mortality. Accordingly, we de...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Öbrink-Hansen, Kristina, Juul, Rasmus Vestergaard, Storgaard, Merete, Thomsen, Marianne Kragh, Hardlei, Tore Forsingdal, Brock, Birgitte, Kreilgaard, Mads, Gjedsted, Jakob
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Clinical Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604352/
https://ncbi.nlm.nih.gov/pubmed/26349823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01347-15
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