Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain’s parenchyma and is a key histopathological hallmark of Alzheimer’s disease (AD). Work on transgenic mice that overexpress Aβ suggests that elevated Aβ levels in the brain are associated with aberrant epileptifo...

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Publicat a:Front Cell Neurosci
Autors principals: Tamagnini, Francesco, Novelia, Janet, Kerrigan, Talitha L., Brown, Jon T., Tsaneva-Atanasova, Krasimira, Randall, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604241/
https://ncbi.nlm.nih.gov/pubmed/26528126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00372
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