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Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism
The well-studied mechanism of ribonuclease A is believed to involve concerted general acid–base catalysis by two histidine residues, His12 and His119. The basic features of this mechanism are often cited to explain rate enhancement by both protein and RNA enzymes that catalyze RNA 2’-O-transphosphor...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4604014/ https://ncbi.nlm.nih.gov/pubmed/25936517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.04.022 |
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