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Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia
22q11.2 deletion carriers show specific cognitive deficits and ∼30% of them develop schizophrenia. One of the disrupted genes is ZDHHC8, which encodes for a palmitoyltransferase. We show that Zdhhc8-deficient mice have reduced palmitoylation of proteins that regulate axonal growth and branching. Ana...
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| Pubblicato in: | Neuron |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4603834/ https://ncbi.nlm.nih.gov/pubmed/25913858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.04.003 |
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