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A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

DISC1 is a strong candidate susceptibility gene for schizophrenia, bipolar disorder, and depression. Using a mouse strain carrying an endogenous Disc1 orthologue engineered to model the putative effects of the disease-associated chromosomal translocation we demonstrate that impaired Disc1 function r...

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Detalhes bibliográficos
Main Authors: Kvajo, Mirna, McKellar, Heather, Arguello, P. Alexander, Drew, Liam J., Moore, Holly, MacDermott, Amy B., Karayiorgou, Maria, Gogos, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383956/
https://ncbi.nlm.nih.gov/pubmed/18458327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802615105
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