Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

TCF3-HLF-fusion positive acute lymphoblastic leukemia (ALL) is currently incurable. Employing an integrated approach, we uncovered distinct mutation, gene expression, and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL. Recurrent intragenic deletions of PA...

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Pubblicato in:Nat Genet
Autori principali: Fischer, Ute, Forster, Michael, Rinaldi, Anna, Risch, Thomas, Sungalee, Stéphanie, Warnatz, Hans-Jörg, Bornhauser, Beat, Gombert, Michael, Kratsch, Christina, Stütz, Adrian M., Sultan, Marc, Tchinda, Joelle, Worth, Catherine L., Amstislavskiy, Vyacheslav, Badarinarayan, Nandini, Baruchel, André, Bartram, Thies, Basso, Giuseppe, Canpolat, Cengiz, Cario, Gunnar, Cavé, Hélène, Dakaj, Dardane, Delorenzi, Mauro, Dobay, Maria Pamela, Eckert, Cornelia, Ellinghaus, Eva, Eugster, Sabrina, Frismantas, Viktoras, Ginzel, Sebastian, Haas, Oskar A., Heidenreich, Olaf, Hemmrich-Stanisak, Georg, Hezaveh, Kebria, Höll, Jessica I., Hornhardt, Sabine, Husemann, Peter, Kachroo, Priyadarshini, Kratz, Christian P., te Kronnie, Geertruy, Marovca, Blerim, Niggli, Felix, McHardy, Alice C., Moorman, Anthony V., Panzer-Grümayer, Renate, Petersen, Britt S., Raeder, Benjamin, Ralser, Meryem, Rosenstiel, Philip, Schäfer, Daniel, Schrappe, Martin, Schreiber, Stefan, Schütte, Moritz, Stade, Björn, Thiele, Ralf, von der Weid, Nicolas, Vora, Ajay, Zaliova, Marketa, Zhang, Langhui, Zichner, Thomas, Zimmermann, Martin, Lehrach, Hans, Borkhardt, Arndt, Bourquin, Jean-Pierre, Franke, Andre, Korbel, Jan O., Stanulla, Martin, Yaspo, Marie-Laure
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603357/
https://ncbi.nlm.nih.gov/pubmed/26214592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3362
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