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Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability
Polynucleotide kinase–phosphatase (PNKP) is a DNA repair factor possessing both 5′-kinase and 3′-phosphatase activities to modify ends of a DNA break prior to ligation. Recently, decreased PNKP levels were identified as the cause of severe neuropathology present in the human microcephaly with seizur...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601665/ https://ncbi.nlm.nih.gov/pubmed/26290337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591363 |
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