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Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida

Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420...

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Bibliografski detalji
Izdano u:Virulence
Glavni autori: Dean, Scott N, van Hoek, Monique L
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601499/
https://ncbi.nlm.nih.gov/pubmed/26155740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21505594.2015.1046029
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