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Engineering enhanced protein disaggregases for neurodegenerative disease

Protein misfolding and aggregation underpin several fatal neurodegenerative diseases, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). There are no treatments that directly antagonize the protein-misfolding events that cause these disor...

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Bibliographic Details
Published in:Prion
Main Authors: Jackrel, Meredith E, Shorter, James
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601286/
https://ncbi.nlm.nih.gov/pubmed/25738979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1020277
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