Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells

Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study via gene deletion has been limited due to the absence of cell lines or mutant models. In this study, we aim to develop an immortalized fibrobl...

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Dades bibliogràfiques
Publicat a:Prion
Autors principals: Choi, WooJae, Kim, Eunji, Yum, Soo-Young, Lee, ChoongIl, Lee, JiHyun, Moon, JoonHo, Ramachandra, Sisitha, Malaweera, Buddika Oshadi, Cho, JongKi, Kim, Jin-Soo, Kim, SeokJoong, Jang, Goo
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601218/
https://ncbi.nlm.nih.gov/pubmed/26217959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1071459
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