Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells

Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study via gene deletion has been limited due to the absence of cell lines or mutant models. In this study, we aim to develop an immortalized fibrobl...

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Detalhes bibliográficos
Publicado no:Prion
Main Authors: Choi, WooJae, Kim, Eunji, Yum, Soo-Young, Lee, ChoongIl, Lee, JiHyun, Moon, JoonHo, Ramachandra, Sisitha, Malaweera, Buddika Oshadi, Cho, JongKi, Kim, Jin-Soo, Kim, SeokJoong, Jang, Goo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601218/
https://ncbi.nlm.nih.gov/pubmed/26217959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1071459
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