Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells

Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study via gene deletion has been limited due to the absence of cell lines or mutant models. In this study, we aim to develop an immortalized fibrobl...

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Vydáno v:Prion
Hlavní autoři: Choi, WooJae, Kim, Eunji, Yum, Soo-Young, Lee, ChoongIl, Lee, JiHyun, Moon, JoonHo, Ramachandra, Sisitha, Malaweera, Buddika Oshadi, Cho, JongKi, Kim, Jin-Soo, Kim, SeokJoong, Jang, Goo
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601218/
https://ncbi.nlm.nih.gov/pubmed/26217959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1071459
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