Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is required for maintaining established tumours is poorly understood. p53 is an important tumour suppressor that acts to restrict proliferation in response...

Full description

Saved in:
Bibliographic Details
Published in:Nature
Main Authors: Xue, Wen, Zender, Lars, Miething, Cornelius, Dickins, Ross A., Hernando, Eva, Krizhanovsky, Valery, Cordon-Cardo, Carlos, Lowe, Scott W.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601097/
https://ncbi.nlm.nih.gov/pubmed/17251933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05529
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items