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MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate and in...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600732/ https://ncbi.nlm.nih.gov/pubmed/26437443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9357 |
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