MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate and in...

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Publicado no:Nat Commun
Main Authors: Meng, Zhipeng, Moroishi, Toshiro, Mottier-Pavie, Violaine, Plouffe, Steven W., Hansen, Carsten G., Hong, Audrey W., Park, Hyun Woo, Mo, Jung-Soon, Lu, Wenqi, Lu, Shicong, Flores, Fabian, Yu, Fa-Xing, Halder, Georg, Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600732/
https://ncbi.nlm.nih.gov/pubmed/26437443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9357
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