Estrogen and progesterone decrease Let-7f miRNA expression and increase IL-23/IL-23R signaling and IL-17A production in severe asthma

BACKGROUND: Women have an increased prevalence of severe asthma compared to men. IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling, which is negatively regulated by Let-7f miRNA. OBJECTIVE: Determine the mechanism by which 17β-estradiol (E2) and progesterone (P4)...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Newcomb, Dawn C., Cephus, Jacqueline Yvonne, Boswell, Madison G., Fahrenholz, John M., Langley, Emily W., Feldman, Amy S., Zhou, Weisong, Dulek, Daniel E., Goleniewska, Kasia, Woodward, Kimberly B., Sevin, Carla M., Hamilton, Robert G., Kolls, Jay, Peebles, R. Stokes
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600442/
https://ncbi.nlm.nih.gov/pubmed/26242299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.046
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