Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels

BACKGROUND: Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young a...

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Détails bibliographiques
Publié dans:Retrovirology
Auteurs principaux: Heigele, Anke, Joas, Simone, Regensburger, Kerstin, Kirchhoff, Frank
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600300/
https://ncbi.nlm.nih.gov/pubmed/26452480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0213-1
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