A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation of RBCs in many disorders. Specifically, ineffective nuclear expulsion (enucleation) during terminal maturation is an obstacle to therapeutic...

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Vydáno v:PLoS Genet
Hlavní autoři: Liang, Raymond, Campreciós, Genís, Kou, Yan, McGrath, Kathleen, Nowak, Roberta, Catherman, Seana, Bigarella, Carolina L., Rimmelé, Pauline, Zhang, Xin, Gnanapragasam, Merlin Nithya, Bieker, James J., Papatsenko, Dmitri, Ma’ayan, Avi, Bresnick, Emery, Fowler, Velia, Palis, James, Ghaffari, Saghi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599908/
https://ncbi.nlm.nih.gov/pubmed/26452208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005526
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