Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II–Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function

BACKGROUND: Multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by angiotensin II (Ang II) in cultured vascular smooth muscle cells (VSMCs), but its function in experimental hypertension has not been explored. The aim of this study was to determine the impact of CaMKII inhib...

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Dades bibliogràfiques
Publicat a:J Am Heart Assoc
Autors principals: Prasad, Anand M, Morgan, Donald A, Nuno, Daniel W, Ketsawatsomkron, Pimonrat, Bair, Thomas B, Venema, Ashlee N, Dibbern, Megan E, Kutschke, William J, Weiss, Robert M, Lamping, Kathryn G, Chapleau, Mark W, Sigmund, Curt D, Rahmouni, Kamal, Grumbach, Isabella M
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599535/
https://ncbi.nlm.nih.gov/pubmed/26077587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001949
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