Differential Control of Calcium Homeostasis and Vascular Reactivity by CaMKII

The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by vasoconstrictors in vascular smooth muscle cells (VSMC), but its impact on vasoconstriction remains unknown. We hypothesized that CaMKII inhibition in VSMC decreases vasoconstriction. Using novel transgenic mice that...

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Hauptverfasser: Prasad, Anand M., Nuno, Daniel W., Koval, Olha M., Ketsawatsomkron, Pimonrat, Li, Weiwei, Li, Hui, Shen, Fred Y., Joiner, Mei-ling A., Kutschke, William, Weiss, Robert M., Sigmund, Curt D., Anderson, Mark E., Lamping, Kathryn G., Grumbach, Isabella M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868483/
https://ncbi.nlm.nih.gov/pubmed/23753415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01508
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