Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II–Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function

BACKGROUND: Multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by angiotensin II (Ang II) in cultured vascular smooth muscle cells (VSMCs), but its function in experimental hypertension has not been explored. The aim of this study was to determine the impact of CaMKII inhib...

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Bibliografische gegevens
Gepubliceerd in:J Am Heart Assoc
Hoofdauteurs: Prasad, Anand M, Morgan, Donald A, Nuno, Daniel W, Ketsawatsomkron, Pimonrat, Bair, Thomas B, Venema, Ashlee N, Dibbern, Megan E, Kutschke, William J, Weiss, Robert M, Lamping, Kathryn G, Chapleau, Mark W, Sigmund, Curt D, Rahmouni, Kamal, Grumbach, Isabella M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2015
Onderwerpen:
Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599535/
https://ncbi.nlm.nih.gov/pubmed/26077587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001949
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