Two-step Ligand Binding in a (βα)(8) Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisA

HisA is a (βα)(8) barrel enzyme that catalyzes the Amadori rearrangement of N′-[(5′-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (ProFAR) to N′-((5′-phosphoribulosyl) formimino)-5-aminoimidazole-4-carboxamide-ribonucleotide (PRFAR) in the histidine biosynthesis pathway, an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Söderholm, Annika, Guo, Xiaohu, Newton, Matilda S., Evans, Gary B., Näsvall, Joakim, Patrick, Wayne M., Selmer, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598979/
https://ncbi.nlm.nih.gov/pubmed/26294764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678086
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