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Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

When a new activity evolves by changes in a pre-existing enzyme this is likely to reduce the original activity, generating a functional trade-off. The properties of this trade-off will affect the continued evolution of both functions. If the trade-off is strong, gene duplication and subsequent diver...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Lundin, Erik, Näsvall, Joakim, Andersson, Dan I.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591586/
https://ncbi.nlm.nih.gov/pubmed/33154742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.588235
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