A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and leukaemia. Although the roles of the PI3K isofo...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K., Bronson, Roderick, Roberts, Thomas M., Gritsman, Kira, Zhao, Jean J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598950/
https://ncbi.nlm.nih.gov/pubmed/26442967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9501
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