A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and leukaemia. Although the roles of the PI3K isofo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K., Bronson, Roderick, Roberts, Thomas M., Gritsman, Kira, Zhao, Jean J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Pub. Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598950/
https://ncbi.nlm.nih.gov/pubmed/26442967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9501
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