Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and limited options for targeted therapies. The comprehensive genetic alterations underlying the pathogenesis of SS are unknown. Here we integrate whole-genome sequencing (n=6), whole-exome sequencing (n=66) and ar...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Kiel, Mark J., Sahasrabuddhe, Anagh A., Rolland, Delphine C. M., Velusamy, Thirunavukkarasu, Chung, Fuzon, Schaller, Matthew, Bailey, Nathanael G., Betz, Bryan L., Miranda, Roberto N., Porcu, Pierluigi, Byrd, John C., Jeffrey Medeiros, L., Kunkel, Steven L., Bahler, David W., Lim, Megan S., Elenitoba-Johnson, Kojo S. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598843/
https://ncbi.nlm.nih.gov/pubmed/26415585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9470
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