Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and limited options for targeted therapies. The comprehensive genetic alterations underlying the pathogenesis of SS are unknown. Here we integrate whole-genome sequencing (n=6), whole-exome sequencing (n=66) and ar...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kiel, Mark J., Sahasrabuddhe, Anagh A., Rolland, Delphine C. M., Velusamy, Thirunavukkarasu, Chung, Fuzon, Schaller, Matthew, Bailey, Nathanael G., Betz, Bryan L., Miranda, Roberto N., Porcu, Pierluigi, Byrd, John C., Jeffrey Medeiros, L., Kunkel, Steven L., Bahler, David W., Lim, Megan S., Elenitoba-Johnson, Kojo S. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598843/
https://ncbi.nlm.nih.gov/pubmed/26415585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9470
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados