The Mga Regulon but Not Deoxyribonuclease Sda1 of Invasive M1T1 Group A Streptococcus Contributes to In Vivo Selection of CovRS Mutations and Resistance to Innate Immune Killing Mechanisms

Invasive M1T1 group A Streptococcus (GAS) can have a mutation in the regulatory system CovRS, and this mutation can render strains hypervirulent. Interestingly, via mechanisms that are not well understood, the host innate immune system's neutrophils select spontaneous M1T1 GAS CovRS hypervirule...

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Bibliografiska uppgifter
I publikationen:Infect Immun
Huvudupphovsmän: Liu, Guanghui, Feng, Wenchao, Li, Dengfeng, Liu, Mengyao, Nelson, Daniel C., Lei, Benfang
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Molecular Pathogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598402/
https://ncbi.nlm.nih.gov/pubmed/26283338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00857-15
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