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Neutrophils Select Hypervirulent CovRS Mutants of M1T1 Group A Streptococcus during Subcutaneous Infection of Mice

Pathogen mutants arise during infections. Mechanisms of selection for pathogen variants are poorly understood. We tested whether neutrophils select mutations in the two-component regulatory system CovRS of group A Streptococcus (GAS) during infection using the lack of production of the protease SpeB...

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Autori principali: Li, Jinquan, Liu, Guanghui, Feng, Wenchao, Zhou, Yang, Liu, Mengyao, Wiley, James A., Lei, Benfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993395/
https://ncbi.nlm.nih.gov/pubmed/24452689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01458-13
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